This paper identifies key ethical considerations when undertaking evidence generation involving children during the mitigation stage of the pandemic (emergency phase), on subject matter relating to COVID-19 once the pandemic has been contained, and once containment policy measures, including lockdowns, have been lifted (post-emergency phase).

While the COVID-19 pandemic is undoubtedly a global crisis, with evidence generation activities raising critical ethical issues that have been captured in the literature and relevant guidelines, there are specificities relating to this emergency that must be considered when unpacking potential ethical issues.

Hence while ethical issues pertaining to evidence generation involving children in emergencies and humanitarian contexts are relevant and should be considered, there are factors that define this ‘special case’ that must be considered from the outset. These will inform the core ethical considerations that need to be addressed.