This information note is intended for use by policy makers, programme managers, and major funders of the health sector response to HIV, in contexts where COVID-19 poses a threat to service continuity for adolescents living with HIV, within national COVID-19 responses. The document succinctly summarizes what we know about COVID-19 risks in this vulnerable population, offers key considerations for safeguarding HIV treatment service continuity, and emphasizes sexual and reproductive health, mental health and psychosocial support as priority needs.